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Bug4AquaHealth: Insect antimicrobial peptides against parasites in the aquaculture industry in the SUDOE territory

ÚLTIMA REVISIÓN: 8 de marzo de 2023

Institución: Faculdade de Ciências da Universidade do Porto


Región: -1

Nombre: Joana


Insect antimicrobial peptides (AMPs) directed against pathogens of human and animal origin have been widely studied. The recent discovery of insect AMPs with antiplasmodial activity in in vitro and in vivo infection models has opened a new area of application for these molecules in the development of antiparasitic drugs. Here, we propose the isolation of AMPs against important parasites in aquaculture from the red palm weevil (RPW), Rhynchophorus ferrugineus (Olivier, 1790), an invasive exotic insect species in the SUDOE region for which we maintain a laboratory colony and which offers excellent conditions for biotechnological applications. The identified antiparasitic peptides will be produced on a large scale by chemical synthesis or recombinant production and formulated as fish feed for bioassays in fish tanks. Various fish features related to exposure to antiparasitic peptides, such as fish health, immune stage and general microbiota, will be investigated.


Perfil Beneficiario:

  • We need a French partner with experience in recombinant protein production, using fermenters to grow recombinant bacterial and yeast hosts, and purification of recombinant proteins.

Idioma: PRT