The RePo-SUDOE project presented, on March 19th, at the Institut Européen de Chimie et Biologie (IECB)/CBMN, its advances in developing experimental methodologies applied to drug repurposing, within the “Chemistry Meets Biology” session. The presentation was delivered by Dr. Ana Álvarez Mena, researcher at IECB in Dr. Birgit Habenstein’s group.
The talk outlined the project’s approach to identifying and validating new therapeutic uses for existing drugs through biophysical characterization of protein–protein interactions. In this context, the role of Surface Plasmon Resonance (SPR) and Bio-Layer Interferometry (BLI) techniques was detailed, used to analyze real-time molecular affinity and binding dynamics, forming the basis of an experimental pipeline for validating drug–target interactions.
The project presented initial results demonstrating the applicability of these methodologies in repurposing processes, as well as their potential to improve efficiency in identifying new therapeutic indications. Future work was defined to consolidate these procedures and extend their use to different case studies within the consortium.
Participation in this scientific forum positioned the RePo-SUDOE experimental approach in an interdisciplinary environment, reinforcing the link between chemistry and biology in developing new drug repurposing strategies.