Research in advanced technologies and its application in the SUDOE space to a topic of economic and social relevance such as thermalism, helping from innovation centers to the most depopulated territories and strengthening networks already established in previous projects such as TERMARED, is the basis of Aquapred. Aquapred is a multi-territorial, multidisciplinary and interdisciplinary project of physics, medicine, pharmacy, chemistry, biology and computing focused on the monitoring and control of thermal/mineromedicinal water of spas and the prediction of contaminants based on the digitisation of real-time data of the fundamental parameters of mineral-medicinal water. The project will determine the fundamental parameters of thermal waters, as well as their ranges of thermal water fluctuation within a thermal facility; its influence on therapeutic safety and water quality and possible relationship models will also be studied. A thermal water hydrobiome model will be established in the project and will be associated with its therapeutic properties. Pilot real-time data collection systems will be developed and installed in resorts in the SUDOE area, in which the parameters will be monitored, using devices specially designed for the function, for subsequent digitisation and analysis. An intelligent system will be developed that, based on these data, allows a control on the elements of water treatment (disinfectants…) and a Deep Learning model that allows predicting the possibility of contaminants in these waters (Legionela, E coli, etc.). Energy efficiency models that optimise consumption and reduce demand will also be applied on the basis of the captured data.