The SUDOE area is one of the most threatened by climate change in Europe. This leads to increased pest pressure on agricultural crops, and responding with chemical phytosanitary products faces serious problems regarding environmental and human health impact. It is necessary to design and deploy among farmers new paradigms based on the principles of integrated crop protection and the use of alternative products, such as biosolutions, whose use is, however, very little widespread due to lack of reference, demonstration, or awareness. Thus, the exchange of experiences is crucial to advance in this field, and the transfer of knowledge in the SUDOE area proves relevant, considering these common problems and crops in that geographical zone. The Biosoludoe project aims to develop Integrated Protection Strategies (IPM) for crops based on biosolutions, in order to evolve towards a more sustainable and environmentally friendly agriculture. This objective will be achieved through a network of 5 Living Labs (LLs), distributed across France (x2), Spain (x2), and Portugal (x1), where these strategies will be conceived from a multi-actor approach and implemented under operational conditions (GT2). The work will focus on 2-3 priority pathosystems / LL in fruit growing and horticulture, as sectors where greater margins for progress are expected. This will be accompanied by shared training and awareness-raising activities for farmers, by means of specific digital pedagogical tools (GT3). These cross-cutting and shared approaches, which will involve all actors in the plant protection value chain, will lead to the elaboration of practical recommendations for regional public policies, as well as a strategy for the deployment of biosolutions and integrated crop protection principles (GT1). The Biosoludoe project brings together 10 partners representing 6 regions of the SUDOE area. This unique approach will serve as an example for other regions of the SUDOE area and Europe.